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Synaptic disorder

10/30/2017
Electron microscope image of synaptic vesicles in the axon terminals of reference motor neurons (left) and Plekhg5-deficient motor neurons (right) at 100,000x magnification. Dysfunctional synaptic vesicles that are degraded in healthy individuals accumula

A Würzburg research team describes a hitherto unknown pathogenic mechanism of motor neuron disorders. This should lead to a rethinking in drug development.

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receptors (green) and G proteins (magenta) at the surface of a living cell

Using a revolutionary live-cell microscopy technique, an international team of scientist has observed for the first time individual receptors for hormones and widely used drugs at work in intact cells.

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Cells under a microscope

Myc proteins play an important role when cells become cancerous. Researchers from the University of Würzburg have studied just how they do this. They might thus open up ways to develop new therapies.

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Quinoa leaf with typical salt bladders.

The quinoa plant might serve as a model for making other crops salt-tolerant. It grows well on saline soils because the excess salt is simply dumped into special bladders on its leaves.

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JMU flags. (Photo: Daniel Peter)

A great success for the University of Würzburg in the first round of the Excellence Strategy: expert committee approves three draft proposals for Excellence Clusters in the fields of physics, chemistry and medicine.

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Attention, collision ahead! What's true for rugby players also applies to pedestrians talking a walk in the city – and can now be calculated. (Photo: Fanny Schertzer / Wikimedia Commons, CC BY 3.0)

How do pedestrians behave in a large crowd? How do they avoid collisions? How can their paths be modelled? A new approach developed by mathematicians from Würzburg and Nice provides answers to these questions.

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Dr. Elmar Wolf

One specific gene is overexpressed in many human tumours. This particular gene is the centre of Elmar Wolf’s research activities. The European Research Council (ERC) has awarded him a "Starting Grant" worth €1.5 million for this purpose.

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People suffering from a fear of heights experience the anxiety also in virtual reality – even though they are aware that they are not really in a dangerous situation. (Photo: VTPlus)

It is possible to unlearn fears. And this works even better when a specific region of the brain has previously been stimulated magnetically. This has been shown by researchers from the Würzburg University Hospital in a new study.

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JMU's main building. (Photo: Daniel Peter)

The prestigious Shanghai Ranking has placed the University of Würzburg among the world’s top 200 universities – as one of four Bavarian and 15 German universities.

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3D model of the proventriculus, a special organ of the tsetse fly: The distribution of the trypanosomes based on the fluorescent cell nuclei is shown in yellow. (Picture: Chair of Zoology I / eLife)

Such detailed images of the pathogen that causes sleeping sickness inside a host are unique so far: They illustrate the manifold ways in which the parasites move inside a tsetse fly.

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Like a spaceship, the complex sugar molecule (coloured) lands exactly on the tumor protein galectin-1, which here looks like a meteorite and is shown in black and white. (Picture: Workgroup Seibel, VCH-Wiley)

Scientists from Würzburg have synthesized a complex sugar molecule which specifically binds to the tumor protein Galectin-1. This could help to recognize tumors at an early stage and to combat them in a targeted manner.

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The larval Drosophila chordotonal organ seen under the scanning electron microscope. This sensory functional unit modulates the processing of mechanical stimuli by means of the latrophilin receptor. Scale: 10 µm. (Photo: Scholz et al., 2017)

About two years ago, scientists from Würzburg discovered that a certain class of receptors is capable of perceiving mechanical stimuli. Now they have begun to unravel the molecular mechanisms behind the discovery.

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Master students from the University of Würzburg during a land survey on wheat fields of the new JECAM site DEMMIN. (Photo: Thorsten Dahms)

Important crop information can be gleaned from satellite data. A new project funded by the German Federal Ministry for Economic Affairs is expected to provide further progress in this field.

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