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Rudolf Virchow Center for Integrative and Translational Bioimaging

Press Archive

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Targeting platelets

05/24/2018

A new Collaborative Research Center will start in July with a total funding of nearly 14 million euros, headed by the German Institute for Experimental Biomedicine in Würzburg. The aim is to decode the complex and insufficiently understood functions of platelets, the so-called thrombocytes. The scientists hope to use these findings to gain new insights into platelet research which allow better treatment of conditions such as heart attack, stroke, acute lung failure and cancer.

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Das Bild zeigt ein Deckglas und dessen Spiegeleffekt mit Goldbeschichtung

G protein-coupled receptors (GPCRs) are the major target molecules for drug discovery. Scientists at the University of Würzburg and the University Hospital Jena have now been able to explore the activation of these receptors in more detail by developing a modern microscopy technique. Increasing the Förster Resonance Energy Transfer (FRET) through the use of specially coated coverslips was the key.

 

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Foto von Dr. Hans Michael Maric im Labor

Since January Dr. Hans Michael Maric is a new group leader at the Rudolf Virchow Center of the University of Würzburg. His research focuses on the development of new drugs based on microarrays.

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Prof. Dr. Bettina Böttcher in front of Titan Krios, one of the world's most powerful electron microscopes (photo: Gunnar Bartsch)

This year, one of the world's most powerful electron microscopes will start operation at the University of Würzburg, providing images of biological molecules of unparalleled quality.

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Picture of a crystal structure of the human RecQ4 Helicase

Scientists from the University of Würzburg solved the structure of the human protein RecQ4 and gained insights into its unusual functional mechanisms, which could help towards the development of new therapeutic strategies against certain tumors.

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Dr. Katrin Heinze, Bio-Imaging-Center, has been appointed as a Professor for Molecular Microscopy at the Rudolf Virchow Center for Experimental Biomedicine at the University of Würzburg as from 24.05.2017.

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[Translate to Englisch:] Das Bild zeigt eine metaphorische Darstellung des regulatorischen Mechanismus der Ubiquitin-Ligase HUWE1.

Scientists at the University of Würzburg have generated new insights into the intricate molecular underpinnings of ubiquitin signaling. Their results may provide new avenues for cancer therapy.

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