Selected Publications from the Heinze Group
Namen der Research highlights:
- Immune-cardiovascular imaging
- Polyneuropathies super-resolved
- Imaging pipelines and modelling
- Core Unit
1. Immune-cardiovascular imaging
Kusch C, Stegner D, Weiss LJ, Nurden P, Burkard P, Johnson D, Bergmeier W, Onursal C, Navarro S, Hackenbroch C, Pfeiffer D, Bonfiglio SI, Meub M, Gross C, Schenk J, Fumagalli V, Mott K, Bender M, Iannacone M, Andres O, Kastenmüller W, Heinze KG, Sauer M, Schulze H, Ley K, Nurden AT, Nieswandt B. Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation. Science. 2026 Jan 22;391(6783):eadu2825. doi: 10.1126/science.adu2825. Epub 2026 Jan 22. PMID: 41570126.
Göb V, Zimmermann L, Hemmen K, Haarmann A, Heinze KG, Schuhmann MK, Stegner D. Platelet-Derived PDGF-A Disrupts Blood-Brain Barrier Integrity in Ischemic Stroke-Brief Report. Arterioscler Thromb Vasc Biol. 2025 Jul;45(7):1166-1174. doi: 10.1161/ATVBAHA.125.321191. Epub 2025 May 15. PMID: 40371467.
Beck S, Öftering P, Li R, Hemmen K, Nagy M, Wang Y, Zarpellon A, Schuhmann MK, Stoll G, Ruggeri ZM, Heinze KG, Heemskerk JWM, Ruf W, Stegner D, Nieswandt B. Platelet glycoprotein V spatio-temporally controls fibrin formation. Nat Cardiovasc Res. 2023 Apr;2(4):368-382. doi: 10.1038/s44161-023-00254-6. Epub 2023 Mar 23. PMID: 37206993; PMCID: PMC10195106.
Bieber M, Schuhmann MK, Bellut M, Stegner D, Heinze KG, Pham M, Nieswandt B, Stoll G. Blockade of Platelet Glycoprotein Ibα Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion. Int J Mol Sci. 2022 Aug 22;23(16):9496. doi: 10.3390/ijms23169496. PMID: 36012752; PMCID: PMC9409377.
Heil HS, Aigner M, Maier S, Gupta P, Evers LMC, Göb V, Kusch C, Meub M, Nieswandt B, Stegner D, Heinze KG. Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy. Platelets. 2022 Aug 18;33(6):849-858. doi: 10.1080/09537104.2021.2023735. Epub 2022 Feb 2. PMID: 35109754.
Stegner D, Göb V, Krenzlin V, Beck S, Hemmen K, Schuhmann MK, Schörg BF, Hackenbroch C, May F, Burkard P, Pinnecker J, Zernecke A, Rosenberger P, Greinacher A, Pichler BJ, Heinze KG, Stoll G, Nieswandt B. Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation. Nat Cardiovasc Res. 2022 Feb;1(2):132-141. doi: 10.1038/s44161-021-00017-1. Epub 2022 Feb 10. PMID: 39195988; PMCID: PMC11358028.
2. Polyneuropathies super-resolved
da Cruz Neris Geßner V, Linke JT, Peulen TO, Appeltshauser L, Sommer C, Brämer D, Geis C, Heinze KG, Doppler K. Super-resolution of nodal and paranodal disruption in anti-pan-neurofascin-associated autoimmune nodopathy. Front Immunol. 2025 Feb 20;16:1540859. doi: 10.3389/fimmu.2025.1540859. PMID: 40051618; PMCID: PMC11882429.
Appeltshauser L, Linke J, Heil HS, Karus C, Schenk J, Hemmen K, Sommer C, Doppler K, Heinze KG. Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy. Neurobiol Dis. 2023 Jun 15;182:106139. doi: 10.1016/j.nbd.2023.106139. Epub 2023 May 3. PMID: 37146836.
Appeltshauser L, Junghof H, Messinger J, Linke J, Haarmann A, Ayzenberg I, Baka P, Dorst J, Fisse AL, Grüter T, Hauschildt V, Jörk A, Leypoldt F, Mäurer M, Meinl E, Michels S, Motte J, Pitarokoili K, Stettner M, Villmann C, Weihrauch M, Welte GS, Zerr I, Heinze KG, Sommer C, Doppler K. Anti-pan-neurofascin antibodies induce subclass-related complement activation and nodo-paranodal damage. Brain. 2023 May 2;146(5):1932-1949. doi: 10.1093/brain/awac418. PMID: 36346134; PMCID: PMC10151189.
3. Imaging pipelines and modelling
Linke JT, Appeltshauser L, Doppler K, Heinze KG. Deep learning-driven automated high-content dSTORM imaging with a scalable open-source toolkit. Biophys Rep (N Y). 2025 Jun 11;5(2):100201. doi: 10.1016/j.bpr.2025.100201. Epub 2025 Feb 28. PMID: 40023500; PMCID: PMC11986538.
Osmanoglu Ö, Özer E, Gupta SK, Heinze KG, Schulze H, Dandekar T. Network Controllability Reveals Key Mitigation Points for Tumor-Promoting Signaling in Tumor-Educated Platelets. Int J Mol Sci. 2025 Nov 5;26(21):10780. doi: 10.3390/ijms262110780. PMID: 41226816; PMCID: PMC12609506.
Peulen TO, Hemmen K, Greife A, Webb BM, Felekyan S, Sali A, Seidel CAM, Sanabria H, Heinze KG. tttrlib: modular software for integrating fluorescence spectroscopy, imaging, and molecular modeling. Bioinformatics. 2025 Feb 4;41(2):btaf025. doi: 10.1093/bioinformatics/btaf025. PMID: 39836627; PMCID: PMC11796090.
Ascheid D, Baumann M, Funke C, Volz J, Pinnecker J, Friedrich M, Höhn M, Nandigama R, Ergün S, Nieswandt B, Heinze KG, Henke E. Image-based modeling of vascular organization to evaluate anti-angiogenic therapy. Biol Direct. 2023 Mar 15;18(1):10. doi: 10.1186/s13062-023-00365-x. PMID: 36922848; PMCID: PMC10018970.
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