Deutsch Intern
GRK 2243 "Understanding Ubiquitylation: From Molecular Mechanisms to Disease"

Projects

The research program comprises 15 research projects in four research areas:

Project A1:
Structural and functional insights into E1-E2 recognition

  • Hermann Schindelin, Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging

Project A2 (completed):
Elucidating regulatory principles in the E2 enzyme family

  • Sonja Lorenz, Max-Planck-Institut für biophysikalische Chemie

Project A3 (completed):
Regulation of the SCF(b-TrCP) ubiquitin ligase via ubiquitylation of its substrate adaptor

  • Nikita Popov, Comprehensive Cancer Center Mainfranken

Project A5:
Elucidating conformational coupling in HECT-type ubiquitin ligases

Project A6:
Cross-regulation between eukaryotic E3 ligases and chlamydial infection

Project B1:
Structural and functional analysis of the Fbw7-Usp28 complex

  • Caroline Kisker, Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging
  • Nikita Popov, Comprehensive Cancer Center Mainfranken
  • Andreas Schlosser, Rudolf-Virchow-Zentrum - Center for Integrative and Translational Bioimaging

Project B2 (completed):
Unmasking E3 ligase-DUB pairs in colorectal cancer

  • Markus Diefenbacher, Biocenter

Project B3 (completed)
Mechanism of substrate recognition by chlamydial DUBs

Project B4:
Function of chlamydial DUBs during infection

Project B5:
Structure-based design and synthesis of antimicrobial DUB inhibitors

Project B6:
Ubiquitin-modifying enzymes of Simkania negevensis and their role in infection

Project C1 (completed):
Role of USP28 in resolving transcription-replication conflicts

  • Markus Diefenbacher, Biocenter
  • Martin Eilers, Biocenter
  • Nikita Popov, Comprehensive Cancer Center Mainfranken

Project C2 (completed):
Stabilization of N-MYC and MYC by Aurora-A

Project C3:
Role of HUWE1-mediated degradation of MIZ-1 in transcriptional elongation

Project C4 (completed):
Control of SREBP stability and transcriptional activity by FBXW7

  • Almut Schulze, Biocenter
  • Nikita Popov, Comprehensive Cancer Center Mainfranken

Project C5:
Role of RNA Polymerase II ubiquitylation in transcription

  • Elmar Wolf, Biocenter

Project C6:
TRIM ubiquitin ligases in MYC-dependent signaling to the innate immune system

Project D1 (completed):
Molecular characterization of the p97 segregase activity

Project D2 (completed):
Dynamics of p97-cofactor interactions under cellular stress conditions

Project D3:
Identification of p97 cofactors and substrates critically affected in neurodegenerative diseases

Project D4:
Development of cofactor-specific small molecule inhibitors for p97